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Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Inferring cortical function in the mouse visual system through large-scale systems neuroscience.

Michael Hawrylycz¹, Costas Anastassiou², Anton Arkhipov²

¹Project MindScope, Allen Institute for Brain Science, Seattle, WA 98103 MikeH@alleninstitute.org ChristofK@alleninstitute.org.

Proceedings of the National Academy of Sciences of the United States of America

|July 7, 2016

Summary

This summary is machine-generated.

Project MindScope investigates the neocortex, the brain region responsible for perception and consciousness. Researchers are testing if this brain tissue is homogeneous, with replicated functional modules across regions, using mouse models and computational approaches.

Keywords:

computation neocortex neural coding simulation visual system

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Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

The neocortex underlies complex cognitive functions like perception, memory, intelligence, and consciousness.
Understanding neocortical organization and function is a major challenge in neuroscience.

Purpose of the Study:

To quantitatively evaluate the hypothesis of neocortical homogeneity with replicated functional modules.
To describe cortical circuitry operation at a computational level by cataloging cellular components and their connectivity.
To model signal transformations from visual input to behavior within the corticothalamic system.

Main Methods:

Utilizing the mouse as a model organism for genetic, physiological, and behavioral studies.
Developing large-scale experimental platforms ('brain observatories') to record neural activity in behaving mice.
Employing computer modeling and theoretical frameworks to analyze neural data and test hypotheses.

Main Results:

Focus on cataloging cellular building blocks, their dynamics, and cell-type-specific connectivities.
Recording activity of large neuronal populations in response to visual stimuli.
Observing and modeling signal processing from retina through the corticothalamic system.

Conclusions:

Project MindScope aims to elucidate the computational principles governing neocortical function.
The study integrates large-scale experimental data with computational modeling for a comprehensive understanding.
Investigating neocortical homogeneity and modularity is key to understanding higher brain functions.