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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
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Heterogeneous Circulating Angiogenic Cell Responses to Acute Maximal Exercise.

Daniel D Shill1, Meagan P Marshburn, Hannah K Hempel

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|July 9, 2016
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Acute maximal exercise significantly increases circulating angiogenic cells (CAC), including progenitor and non-progenitor types. These responses vary between sexes and may be influenced by menstrual cycle phase and contraceptive use.

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Area of Science:

  • Cardiovascular Physiology
  • Exercise Immunology
  • Endothelial Biology

Background:

  • Circulating angiogenic cells (CAC) are crucial for angiogenesis and endothelial repair.
  • CAC populations within peripheral blood mononuclear cells (PBMC) are modulated by exercise.
  • Understanding exercise-induced CAC changes is vital for cardiovascular health research.

Purpose of the Study:

  • To investigate the impact of acute maximal exercise on specific CAC subpopulations in healthy adults.
  • To analyze changes in CD31, CD62E, CD14/CD31, CD34/VEGFR2, CD3/CD31, and CD3 PBMC.
  • To explore sex-specific differences and potential influences of the menstrual cycle and contraceptive use on CAC responses.

Main Methods:

  • Blood samples were collected pre- and post-maximal graded treadmill exercise.
  • Flow cytometry was employed for the quantitative analysis of PBMC subpopulations.
  • Specific cell markers (CD31, CD62E, CD14, CD34, VEGFR2, CD3) were assessed.

Main Results:

  • Maximal exercise significantly increased lymphocytic CD31, monolymphocytic CD31, CD62E, CD14/CD31, and CD34/VEGFR2 PBMC.
  • CD62E and CD14/CD31 PBMC increases were significantly higher in women.
  • Menstrual cycle phase and contraceptive use showed potential modulatory effects on CAC levels.

Conclusions:

  • Acute maximal exercise elicits a substantial CAC response involving diverse cell types.
  • Sex-specific differences in CD62E and CD14/CD31 PBMC responses to exercise were observed.
  • Menstrual cycle phase and contraceptive status may influence exercise-induced CAC mobilization.