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Chronic Pharyngitis01:23

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Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
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Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
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Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
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Infectious Chronic Rhinosinusitis.

Sumit Bose1, Leslie C Grammer1, Anju T Peters1

  • 1Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

The Journal of Allergy and Clinical Immunology. in Practice
|July 10, 2016
PubMed
Summary
This summary is machine-generated.

Chronic rhinosinusitis (CRS) is a persistent inflammatory condition. Infectious CRS, often linked to bacterial infections and immune deficiencies, requires tailored treatments like antimicrobials and potentially immunoglobulin therapy.

Keywords:
BacterialExacerbationImmunodeficiencyInfectiousMicrobiomePathogenesisRhinosinusitisSinonasal

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Area of Science:

  • Otolaryngology
  • Immunology
  • Infectious Diseases

Background:

  • Chronic rhinosinusitis (CRS) is a widespread inflammatory condition impacting numerous individuals globally.
  • Its pathogenesis is multifactorial, involving genetics, sinonasal microbiome, infections, and environmental factors.
  • CRS frequently co-occurs with other conditions such as asthma, allergic rhinitis, bronchiectasis, and certain immunodeficiencies.

Purpose of the Study:

  • To review the current understanding of chronic rhinosinusitis (CRS), with a focus on infectious CRS.
  • To discuss the etiology, comorbidities, and treatment strategies for CRS, particularly in the context of infectious and immunodeficiency-related cases.
  • To highlight the need for advancements in targeted therapies and biomarkers for CRS.

Main Methods:

  • Literature review of chronic rhinosinusitis (CRS) pathogenesis, classification, and treatment.
  • Analysis of the role of infections and humoral immunodeficiency in CRS.
  • Examination of current therapeutic approaches, including antimicrobial therapy, corticosteroids, and immunoglobulin replacement.

Main Results:

  • Infectious CRS is often initiated by viral infections, leading to chronic bacterial infections.
  • Humoral antibody deficiencies are associated with recurrent or difficult-to-treat CRS.
  • Standard treatments include antimicrobials, corticosteroids, and nasal irrigations; severe cases with immunodeficiency may need immunoglobulin replacement therapy.

Conclusions:

  • Chronic rhinosinusitis is a complex disease with diverse contributing factors and comorbidities.
  • Infectious CRS and CRS associated with humoral immunodeficiency present unique challenges requiring specific treatment strategies.
  • Further research is essential to develop targeted therapies and reliable biomarkers for improved CRS management.