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Updated: Mar 18, 2026

Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein
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Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction

Sara Iozzi1, Rosaria Remelli2, Barbara Lelli3

  • 1Pharmacology Department, Sienabiotech S.p.A, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy; Dipartimento di Biotecnologie, Università Degli Studi di Siena, Via Fiorentina 1, 53100 Siena, Italy.

ISRN Molecular Biology
|July 12, 2016
PubMed
Summary

A novel small molecule, NCI8642, effectively blocks Dickkopf-1 (DKK1) from inhibiting Wnt signaling by targeting the LRP6 receptor. This discovery offers new therapeutic avenues for diseases linked to DKK1 dysregulation.

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