[COMPARATIVE ANALYSIS OF REPOA (EPOKRIN) AND REPOB (RECORMON) INFLUENCE ON ERYTHROPOIESIS IN VIVO AND IN VITRO]
Abstract:
The study performed on erythroblastic island cultures and rats with experimental polycythemia showed that recormon and epokrin stimulated erythropoiesis in erythroblastic islands both in vitro and in vivo. In cell cultures, recormon activates the formation of erythroblastic islands de novo and de repeto 1.3 times better than epokrin (p < 0.05). Erythroid cells exbhibited same reaction to epokrin and recormon in vivo: the number of erythroblastic islands in the bone marrow increased 3.4 times (p < 0.05) and the number of reticulocytes in the blood increased 2.2 times (p < 0.05).
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