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Updated: Mar 14, 2026
Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
Published on: May 26, 2021
Effect of Preliminary Injection of Bone Marrow Cell Total RNA on Erythropoiesis Recovery Dynamics in Rats Exposed to
N M Gevorkyan1, N V Tishevskaya2, A A Bolotov3
1V. N. Orekhovich Research Institute of Biomedical Chemistry, the Russian Academy of Medical Sciences, Moscow, Russia.
Abstract:
Total RNA from the bone marrow of healthy donor rats was injected to experimental rats 6 h, 2 h, or 30 min prior to a single γ-irradiation in the sublethal dose of 6 Gy. Injection total RNA 30 min prior to the exposure most effectively restored erythropoiesis in experimental animals. In 5 days, reticulocyte count in these animals 30-fold surpassed the control (injection of 0.9% NaCl). In 12 days, the content of new erythroblastic islands in the bone marrow in rats injected with the total RNA 2 h or 30 min prior to irradiation increased significantly and erythropoiesis recovery activation was observed.
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