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Updated: Mar 17, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

P-TEFb goes viral.

Justyna Zaborowska¹, Nur F Isa^1,2, Shona Murphy¹

¹Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology

|July 16, 2016

Summary

This summary is machine-generated.

Positive transcription elongation factor b (P-TEFb) regulates gene transcription and RNA processing. Viral factors modulate cyclin-dependent kinase 9 (CDK9) activity, suggesting CDK9-targeted antivirals could be effective.

Keywords:

CDK9 CTD EBV HIV HSV HTLV P-TEFb

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Published on: May 27, 2011

Area of Science:

Molecular Biology
Virology
Biochemistry

Background:

Positive transcription elongation factor b (P-TEFb) is a crucial kinase complex in human cells, composed of cyclin-dependent kinase 9 (CDK9) and cyclin T.
P-TEFb facilitates productive gene transcription by phosphorylating negative elongation factors and recruits transcription/RNA processing factors via CTD phosphorylation of RNA polymerase II.
CDK9 also phosphorylates p53, a tumor suppressor vital for cellular stress responses.

Purpose of the Study:

To review the regulatory mechanisms of CDK9 function by viral gene products.
To explore the implications of CDK9's role in viral life cycles for antiviral drug development.

Main Methods:

Literature review focusing on the interaction between viral factors and CDK9.
Analysis of existing research on CDK9's role in transcription, RNA processing, and viral replication.

Main Results:

Numerous viral factors interact with and modulate the activity of CDK9.
CDK9 plays a central role in the life cycles of various viruses.
Viral modulation of CDK9 impacts host cell transcription and RNA processing.

Conclusions:

CDK9 is a key target for viral manipulation.
Targeting the interaction between viral products and P-TEFb presents a promising strategy for developing novel antiviral agents.