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Continuous Effector CD8(+) T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative

H Hamlet Chu1, Shiao-Wei Chan1, John Paul Gosling2

  • 1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA.

Immunity
|July 17, 2016
PubMed
Summary

Persistent infections involve continuous production of CD8(+) effector T (Teff) cells from a unique intermediate T cell population. This sustained response relies on ongoing antigen presentation, crucial for controlling chronic infections.

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