Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
Stem Cell Culture01:17

Stem Cell Culture

6.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.5K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.2K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.2K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.1K
Lineage Commitment01:21

Lineage Commitment

4.5K
Commitment is the  process whereby stem cells:
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sustained-Release RANKL Microneedles for Safe Orthodontic Acceleration.

Journal of dental research·2026
Same author

Three-cavity clearance significantly reduces the postoperative fistula rate and abscess recurrence following glandular perianal abscess: a single-center real-world study.

Techniques in coloproctology·2026
Same author

[Clinical pathway of gel-based preparations for wound healing of diabetic foot ulcer].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2026
Same author

[Maggot alleviates imiquimod-induced psoriasis-like skin lesions in mice by inhibiting immune stress and complement activation].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2024
Same author

Proton and molecular permeation through the basal plane of monolayer graphene oxide.

Nature communications·2023
Same author

[Exploration of functional reconstruction and rehabilitation strategies for patients with destructive electric burns].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2023

Related Experiment Video

Updated: Mar 17, 2026

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

1.0K

Bone marrow cells differentiation into organ cells using stem cell therapy.

Y-J Yang1, X-L Li, Y Xue

  • 1Department of Hematology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China. xzyyj2013@126.com.

European Review for Medical and Pharmacological Sciences
|July 19, 2016
PubMed
Summary
This summary is machine-generated.

Bone marrow cells (BMCs) show potential for regenerating various cell types, including neural and cardiac cells, offering therapeutic possibilities for diseases like Alzheimer's and after heart attacks. Further research is needed for human applications of stem cell therapy.

More Related Videos

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

11.9K
Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
10:25

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

10.2K

Related Experiment Videos

Last Updated: Mar 17, 2026

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

1.0K
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

11.9K
Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
10:25

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

10.2K

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Cellular Differentiation

Background:

  • Bone marrow cells (BMCs) are versatile progenitor cells with the capacity to differentiate into multiple cell lineages.
  • Multipotent adult progenitor cells (MAPCs), derived from bone marrow stromal and mesenchymal cells, exhibit differentiation potential into various germ layers.
  • Mesenchymal stem cells from adult bone marrow are recognized for their neural regeneration capabilities.

Purpose of the Study:

  • To explore the regenerative potential of bone marrow cells (BMCs) for various tissues and cell types.
  • To highlight the therapeutic applications of stem cell therapy (SCT) in conditions like myocardial infarction and central nervous system disorders.
  • To discuss the differentiation capacity of multipotent adult progenitor cells (MAPCs) and their relevance in regenerative medicine.

Main Methods:

  • Review of existing literature on bone marrow cell differentiation and therapeutic applications.
  • Analysis of studies demonstrating BMCs' potential to regenerate cardiac myocytes and neural cells.
  • Examination of research on multipotent adult progenitor cells (MAPCs) and their differentiation capabilities.

Main Results:

  • Bone marrow cells (BMCs) can differentiate into diverse cell types, including cardiac myocytes, neural cells, hepatocytes, chondrocytes, and adipocytes.
  • Stem cells derived from BMCs have shown promise in regenerating cardiac tissue after myocardial infarction and neural cells for CNS disorders.
  • Multipotent adult progenitor cells (MAPCs) demonstrate differentiation into mesenchymal, neuroectodermal, and endodermal lineages in vitro.

Conclusions:

  • Bone marrow cells (BMCs) represent a significant source for regenerative medicine, with potential applications in treating degenerative diseases and tissue damage.
  • Stem cell therapy (SCT) using BMCs holds promise for conditions such as Alzheimer's, Parkinson's, and heart disease, though ethical considerations and human trials are ongoing.
  • The regenerative capacity of BMCs and MAPCs underscores their importance in developing novel therapeutic strategies for a wide range of diseases.