[Effect of holotoxin A1 on microviscosity of model and biological membranes]

Behavior of hydrophobic probes of 5-doxylstearol acid and pyrene in phosphatidylcholine liposomes modified by sterols isolated from Far East holothurian tissues was studied. The introduction of delta 7-sterol xylosides and delta 5-sterol sulfates into liposomes was shown to result in an increase of the membranes microviscosity. When the liposome suspension was added with holotoxin A1 a supplementary increase of microviscosity was observed, which was obviously a consequence of glycosides +non built into the membranes.