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Optic Disc Hemorrhages and Laminar Disinsertions in Glaucoma
Glen P Sharpe1, Vishva M Danthurebandara1, Jayme R Vianna1
1Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Canada.
Ophthalmology
|July 20, 2016
Summary
Structural abnormalities of the lamina cribrosa, specifically laminar disinsertions, were more common in glaucoma patients with optic disc hemorrhages. However, the location of these hemorrhages and disinsertions did not consistently overlap in individual patients.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Optic Nerve Head Imaging
Background:
- Optic disc hemorrhages (ODHs) are a clinical sign in glaucoma.
- Structural abnormalities of the lamina cribrosa may be associated with ODHs.
- Understanding this relationship is crucial for glaucoma management.
Purpose of the Study:
- To investigate the association between structural abnormalities of the lamina cribrosa and the presence of optic disc hemorrhages.
- To determine the spatial concordance between disc hemorrhages and laminar disinsertions from the sclera in glaucoma patients.
Main Methods:
- Prospective study of open-angle glaucoma patients.
- Identified eyes with optic disc hemorrhage (ODH+ group) and without (ODH- group).
- Utilized enhanced depth imaging optical coherence tomography to assess laminar disinsertions, with scores of 3 or higher considered significant.
Main Results:
- Laminar disinsertions were found in 96% of ODH+ eyes versus 52% of ODH- eyes.
- Disinsertions occurred twice as frequently in eyes with ODHs.
- Despite frequent disinsertions, only 39% of ODHs spatially corresponded to a laminar disinsertion in individual patients.
Conclusions:
- Laminar disinsertions are more frequent in glaucoma eyes with optic disc hemorrhages.
- The spatial concordance between optic disc hemorrhages and laminar disinsertions is poor in individual patients.
- Structural abnormalities of the lamina cribrosa may contribute to ODHs, but not always in a predictable location.
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