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Future Targets for Female Sexual Dysfunction.

Melissa Farmer1, Hana Yoon2, Irwin Goldstein3

  • 1Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

The Journal of Sexual Medicine
|July 21, 2016
PubMed
Summary
This summary is machine-generated.

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Novel treatments for female sexual dysfunction require targeting molecular and cellular pathways. Future therapies may involve regenerative medicine and combined central and peripheral approaches for optimal results.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pharmacology

Background:

  • Female sexual function involves complex interactions of nervous, vascular, and endocrine systems.
  • Developing effective treatments for female sexual dysfunction (FSD) is challenging.
  • Targeting neurochemical pathways is crucial for enhancing FSD therapies.

Purpose of the Study:

  • To create an evidence-based consensus report on therapeutic targets for FSD.
  • To integrate current knowledge on molecular and cellular targets for female sexual function.
  • To guide the development of novel pharmacological treatments for FSD.

Main Methods:

  • A state-of-the-art review was conducted over one year.
  • International expert opinions were gathered through a consensus process.
Keywords:
Female Sexual DysfunctionPharmacotherapyTreatment

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  • Evidence-based medical literature was graded, and discussions were held.

    • Main Results:

    • Current knowledge on therapeutic manipulation of molecular and cellular targets was condensed.
    • The need for research to improve genital tissue integrity and responsiveness was highlighted.
    • Optimizing the appraisal of sexual cues is essential for treatment success.

    Conclusions:

    • Future FSD treatments may include gene therapy, stem cell therapies, and regenerative medicine.
    • Modulating emotional learning circuits and restoring tactile sensation are potential targets.
    • Combining central and peripheral therapies could enhance treatment outcomes.