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Studying epigenetic complexes and their inhibitors with the proteomics toolbox

David Weigt1, Carsten Hopf1, Guillaume Médard2

  • 1Center for Applied Research in Biomedical Mass Spectrometry (ABIMAS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany ; HBIGS International Graduate School of Molecular and Cellular Biology, Heidelberg University, Im Neuenheimer Feld 501, 69120 Heidelberg, Germany.

Clinical Epigenetics
|July 21, 2016
PubMed
Summary

New affinity probes help researchers understand epigenetic drugs. These tools identify drug targets and off-target effects, advancing the study of epigenetic modifier proteins and their complexes.

Keywords:
Affinity matrixAffinity purificationComplex identificationImmunoaffinity purificationPhoto-cross-linkingTarget deconvolution

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