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Effect of Atorvastatin on the Disease Activity and Severity of Rheumatoid Arthritis: Double-Blind Randomized

Karim Mowla1, Elham Rajai1, Ali Ghorbani2

  • 1Faculty, Department of Rheumatology, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, Iran .

Journal of Clinical and Diagnostic Research : JCDR
|July 21, 2016
PubMed

Insights

Atorvastatin significantly reduced disease activity and inflammatory markers in rheumatoid arthritis patients. This study demonstrates the anti-inflammatory benefits of atorvastatin in managing rheumatoid arthritis symptoms.

Area of Science:

  • Rheumatology
  • Pharmacology
  • Immunology

Background:

  • Statins, HMG-CoA reductase inhibitors, possess anti-inflammatory properties.
  • These properties may be beneficial in managing rheumatoid arthritis (RA) disease activity and inflammation.

Purpose of the Study:

  • To evaluate the anti-inflammatory effects of statins in patients with rheumatoid arthritis.
  • To determine if atorvastatin can suppress disease activity and inflammatory markers in RA.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 80 Iranian RA patients (19-75 years).
  • Participants received either atorvastatin 40 mg daily or placebo, alongside existing DMARDs.
  • Assessments included Disease Activity Score-28 (DAS28), CRP, ESR, swollen joint count (SJC), and tender joint count (TJC) pre- and post-intervention.

Main Results:

  • Atorvastatin significantly decreased DAS28 compared to placebo (p<0.001).
  • Significant reductions in SJC, TJC, CRP, and ESR were observed in the atorvastatin group versus placebo.
  • The analysis was based on intention to treat.

Conclusions:

  • Atorvastatin effectively suppresses RA disease activity and inflammatory factors.
  • The drug is particularly beneficial for RA patients with moderate to high inflammation levels.
Abstract

Keywords:
Anti-inflammatory agentsErythrocyte sedimentation rateHMG-CoASwollen joint countTender joint count

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