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Hypertriglyceridemia‑Induced Acute Pancreatitis Compared With Non-Hypertriglyceridemia Acute Pancreatitis: A
Zahra Farhangiyan1,2, Leila Moradi1,2, Mehrdad Vaziri1
1Department of Internal Medicine, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.
Health Science Reports
|June 12, 2026
Summary
Hypertriglyceridemia-induced acute pancreatitis (HTGAP) leads to more severe disease and higher complication rates compared to other forms of acute pancreatitis (AP). Early recognition and management are crucial for better patient outcomes.
Area of Science:
- Gastroenterology
- Internal Medicine
- Clinical Research
Background:
- Hypertriglyceridemia-induced acute pancreatitis (HTGAP) is a distinct subtype of acute pancreatitis (AP).
- Comparative data on risk factors, disease severity, and outcomes between HTGAP and non-HTGAP are limited.
- Understanding these differences is crucial for effective clinical management.
Purpose of the Study:
- To compare the risk factors, disease severity, and clinical outcomes of patients with HTGAP versus non-HTGAP.
- To identify specific characteristics associated with HTGAP.
- To inform clinical practice regarding the management of severe pancreatitis.
Main Methods:
- A retrospective case-control study was conducted at a single center.
- 150 patients with HTGAP and 150 patients with non-HTGAP were included.
- Demographic data, severity scores (Ranson, APACHE II, MCTSI), complications, and length of hospital stay were compared.
Main Results:
- HTGAP patients were younger, had higher BMI, and experienced significantly more complications (e.g., ARDS, sepsis, pancreatic necrosis, renal failure).
- HTGAP was associated with higher severity scores (Ranson, APACHE II, MCTSI) and longer hospital stays.
- No in-hospital mortality was observed in either group during the study period.
Conclusions:
- HTGAP presents with a more severe clinical profile and increased complication rates compared to non-HTGAP.
- Early identification and prompt management strategies are essential for patients with HTGAP.
- Limitations include the retrospective, single-center design and lack of multivariable analysis.
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