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Related Experiment Videos

Oleamidopropyl dimethylamine.

A C de Groot1

  • 1Department of Dermatology, Carolus and Willem-Alexander Hospital, s-Hertogenbosch (The Netherlands).

Dermatosen in Beruf Und Umwelt. Occupation and Environment
|May 1, 1989
PubMed
Summary
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Oleamidopropyl dimethylamine in cosmetics can cause allergic contact dermatitis. This emulsifier, found in baby lotions, poses a risk, especially on damaged skin.

Area of Science:

  • Dermatology
  • Cosmetic Science
  • Allergology

Background:

  • Oleamidopropyl dimethylamine is a cationic emulsifier frequently implicated in cosmetic sensitization.
  • Allergic contact dermatitis (ACD) from cosmetics is a significant clinical concern.

Purpose of the Study:

  • To investigate the prevalence of oleamidopropyl dimethylamine allergy in patients with cosmetic-related ACD.
  • To analyze cross-reactivity patterns among related amideamine emulsifiers.

Main Methods:

  • Retrospective analysis of 119 patients with cosmetic-related ACD.
  • Patch testing with oleamidopropyl dimethylamine and related emulsifiers in 13 allergic patients.

Main Results:

  • 11% (13/119) of patients showed allergy to oleamidopropyl dimethylamine.

Related Experiment Videos

  • High cross-reactivity observed with ricinoleamidopropyl dimethylamine lactate and tallowamidopropyl dimethylamine (85%).
  • Significant cross-reactivity also noted with lauramidopropyl dimethylamine (75%) and myristamidopropyl dimethylamine (46%).

    • Conclusions:

    • A 0.3% concentration of oleamidopropyl dimethylamine in leave-on cosmetics presents a definite risk for inducing and eliciting contact allergies.
    • Risk is heightened with application to damaged skin or the periorbital area.