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Updated: Mar 17, 2026

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

Special Issue: Genome Editing and Gene Therapy.

A A Zamyatnin¹

¹Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Moscow, 119991, Russia. zamyat@belozersky.msu.ru.

Biochemistry. Biokhimiia

|July 25, 2016

Summary

Gene therapy advances molecular medicine by enabling genetic corrections for diseases. Overcoming technical challenges is key to developing safe and effective gene therapy agents for wider clinical use.

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Area of Science:

Molecular Medicine
Genetics
Biotechnology

Background:

Gene therapy is a rapidly advancing field focused on correcting pathological processes through genetic methods.
Current gene therapy approaches face technical limitations hindering widespread clinical application.

Discussion:

This special issue explores modern methodologies for creating innovative gene therapy agents.
Focus is placed on enhancing the efficacy and safety of gene therapy delivery systems.

Key Insights:

Novel strategies are being developed to address existing technical hurdles in gene therapy.
The research emphasizes the creation of effective and safe gene therapy agents.

Outlook:

Future gene therapy development aims for broader clinical adoption and improved patient outcomes.
Continued innovation in gene therapy holds significant promise for treating genetic disorders.

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