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Updated: Mar 17, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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Circular RNAs and systemic lupus erythematosus.
Lian-Ju Li1, Qing Huang1, Hai-Feng Pan1
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, China.
Experimental Cell Research
|July 25, 2016
Summary
Circular RNAs (circRNAs) are a novel class of noncoding RNAs involved in gene regulation. This review explores their role in diseases like systemic lupus erythematosus (SLE), suggesting potential therapeutic applications.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Circular RNAs (circRNAs) are noncoding RNAs forming closed circles, adding a layer to post-transcriptional gene regulation.
- circRNA identification is advancing with high-throughput sequencing but remains challenging.
- circRNA biogenesis involves canonical splicing, sequence properties, and regulatory factors.
Purpose of the Study:
- To review the identification, biogenesis, and functions of circRNAs.
- To discuss the association of circRNAs with human diseases.
- To explore the potential role of circRNAs in systemic lupus erythematosus (SLE).
Main Methods:
- Literature review of circRNA research.
- Analysis of studies on circRNAs in disease.
- Exploration of miRNA sponging and gene regulation mechanisms.
Main Results:
- circRNAs function in gene regulation, including miRNA sponging (e.g., CDR1as/miR-7).
- circRNAs are implicated in various human diseases, including cancers.
- MicroRNAs (miRNAs) play a role in SLE pathogenesis.
Conclusions:
- circRNAs may be associated with SLE due to their regulatory functions and miRNA interactions.
- circRNAs represent potential therapeutic targets for SLE.
- Further research is crucial to elucidate the relationship between circRNAs and SLE.
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