Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conduction System of the Heart01:19

Conduction System of the Heart

14.4K
Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
14.4K
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers01:24

Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

2.2K
Adrenergic stimulation generally impacts cardiac rate and rhythm. Specifically, stimulation of the β-adrenoceptors triggers an increase in intracellular calcium ion influx and pacemaker currents, which may cause arrhythmias. Catecholamines like adrenaline also demonstrate β2-adrenoceptor-mediated hypokalemia, impacting cardiac action potential and disrupting the normal cardiac rhythm. Class II antiarrhythmic drugs are β-adrenoceptor antagonists or β-blockers, which...
2.2K
Pulse rhythm01:30

Pulse rhythm

1.6K
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.6K
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

591
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
591
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

1.8K
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
1.8K
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

10.2K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Outcomes With Class 1C Antiarrhythmic Drug Use in Atrial Fibrillation.

Journal of the American Heart Association·2026
Same author

Mortality, Hospitalization, and Cardiac Interventions Among Patients With Mitral Valve Prolapse <65 Years of Age.

Journal of the American Heart Association·2026
Same author

Mortality, Hospitalization, and Cardiac Interventions in Patients With Atrial Fibrillation Aged <65 Years.

Circulation. Arrhythmia and electrophysiology·2024
Same author

Serum glutamate was elevated in children aged 3-10 years with autism spectrum disorders when they were compared with controls.

Acta paediatrica (Oslo, Norway : 1992)·2018
Same author

Antiphospholipid antibody-mediated effects in an arterial model of thrombosis are dependent on Toll-like receptor 4.

Lupus·2015
Same author

The dual role of innate immunity in antiphospholipid syndrome and systemic lupus erythematosus.

Lupus·2014
Same journal

Understanding health insurance and the delay in care for partial meniscectomies: a comparison between public and private coverage.

The Physician and sportsmedicine·2026
Same journal

Injury incidence and risk factors in youth American football versus soccer: a national emergency department analysis.

The Physician and sportsmedicine·2026
Same journal

Links between concussion history, hypertension, and hypertension contributing factors among adolescent football athletes.

The Physician and sportsmedicine·2026
Same journal

Core muscle endurance and balance as predictors of lateral ankle sprain in adolescent team-sport athletes: a prospective cohort study.

The Physician and sportsmedicine·2026
Same journal

Impact of Achilles tendon rupture on performance and career outcomes in NFL players: a matched cohort study.

The Physician and sportsmedicine·2026
Same journal

Pre-existing injuries and illnesses in trail running: sex-based epidemiological findings from a 2022 forest marathon.

The Physician and sportsmedicine·2026
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

14.1K

Recent Developments in Cardiac Pacemakers: Rate-Responsive Pacing.

T Tordjman, M Doust, D Salem

    The Physician and Sportsmedicine
    |July 27, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Modern pacemakers now offer rate-responsive pacing, sensing skeletal muscle activity to adjust heart rate during exercise. This innovation improves cardiac output and exercise tolerance for patients.

    More Related Videos

    Translational Rabbit Model of Chronic Cardiac Pacing
    06:14

    Translational Rabbit Model of Chronic Cardiac Pacing

    Published on: January 6, 2023

    3.2K
    Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
    12:45

    Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

    Published on: December 11, 2017

    11.1K

    Related Experiment Videos

    Last Updated: Mar 17, 2026

    Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
    10:08

    Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

    Published on: February 17, 2018

    14.1K
    Translational Rabbit Model of Chronic Cardiac Pacing
    06:14

    Translational Rabbit Model of Chronic Cardiac Pacing

    Published on: January 6, 2023

    3.2K
    Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
    12:45

    Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

    Published on: December 11, 2017

    11.1K

    Area of Science:

    • Cardiology
    • Biomedical Engineering
    • Physiology

    Background:

    • Cardiac pacemakers have advanced significantly over 30 years.
    • Early pacemakers provided fixed-rate stimulation, often in a single heart chamber.
    • Recent advancements enable sensing and stimulating both the atrium and ventricle for physiologic pacing.

    Purpose of the Study:

    • To describe the evolution of cardiac pacemakers.
    • To highlight the development of rate-responsive pacemakers.
    • To explain how new technology enhances patient exercise tolerance.

    Main Methods:

    • Review of pacemaker technology evolution over three decades.
    • Description of single-chamber pacemakers with skeletal muscle activity sensing.
    • Analysis of rate-responsive pacing mechanisms.

    Main Results:

    • Pacemakers have progressed from simple fixed-rate devices to sophisticated dual-chamber units.
    • New single-chamber pacemakers sense skeletal muscle activity.
    • Rate-responsive pacing increases heart rate with physical activity.

    Conclusions:

    • Pacemaker technology has evolved to provide more physiologic pacing.
    • Rate-responsive pacemakers improve atrioventricular synchrony and cardiac output during exercise.
    • This advancement leads to enhanced exercise tolerance for pacemaker patients.