Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.7K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.7K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

8.3K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
8.3K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.8K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.8K
Contact-dependent Signaling01:19

Contact-dependent Signaling

48.3K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
48.3K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

7.0K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
7.0K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

19.0K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
19.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human progenitor cells for bone engineering applications.

Current molecular medicine·2013
Same author

Teratoma formation of human embryonic stem cells in three-dimensional perfusion culture bioreactors.

Journal of tissue engineering and regenerative medicine·2012
Same author

[Are investment activity and backlog in investments risks for university medicine in Germany?].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2009
Same author

[Biomechanical evaluation of biointegrable suture anchors composed of bovine compact bone in a pull-to-failure test in porcine tibial head specimens].

Zeitschrift fur Orthopadie und ihre Grenzgebiete·2006
Same author

[Third level centers in Integrated Health Care: no room, no interest, no needs?].

Clinical research in cardiology : official journal of the German Cardiac Society·2006
Same author

Controlled respiratory gas delivery to embryonic renal epithelial explants in perfusion culture.

Tissue engineering·2004
Same journal

Quantitative models of photoreceptor metabolisms: implications for rod outer segment length, retinal glycolysis and choroidal blood flow.

Physical biology·2026
Same journal

Mechanical interactions govern self-organized ordering in bacterial colonies on surfaces.

Physical biology·2026
Same journal

Robust chemotaxis beyond sensing limits: signal, noise, and strategy.

Physical biology·2026
Same journal

Ecological dynamics of pro-tumor and anti-tumor teams in the tumor microenvironment.

Physical biology·2026
Same journal

Swarms of female<i>Anopheles gambiae</i>mosquitoes may fracture when perturbed.

Physical biology·2026
Same journal

How exercise scheduling affects IL-6-mediated tumor suppression: a fixed exercise volume perspective.

Physical biology·2026
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy
15:13

High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy

Published on: July 25, 2014

11.9K

Multiparticle collision dynamics for diffusion-influenced signaling pathways.

R Strehl1, K Rohlf

  • 1Department of Mathematics, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada.

Physical Biology
|July 29, 2016
PubMed
Summary
This summary is machine-generated.

A new simulation method accurately models diffusion-influenced reactions by including species-specific diffusion and reactant control. This particle-based approach is efficient for detailed trajectory and reaction analysis, as shown in bacterial chemotaxis simulations.

More Related Videos

Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy
12:06

Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy

Published on: February 1, 2017

11.6K
Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

9.3K

Related Experiment Videos

Last Updated: Mar 17, 2026

High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy
15:13

High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy

Published on: July 25, 2014

11.9K
Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy
12:06

Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy

Published on: February 1, 2017

11.6K
Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

9.3K

Area of Science:

  • Computational chemistry and biophysics
  • Biochemical reaction modeling
  • Mesoscopic simulation techniques

Background:

  • Diffusion-influenced reactions are crucial in biological systems.
  • Accurate modeling requires capturing both diffusion and reaction kinetics.
  • Existing methods may lack efficiency or detailed spatial resolution.

Purpose of the Study:

  • To present an efficient and accurate simulation method for diffusion-influenced reaction networks.
  • To extend reactive multiparticle collision dynamics (rMPCD) with key physical parameters.
  • To provide a tool for systems requiring detailed particle trajectories and local reaction information.

Main Methods:

  • Developed an off-lattice particle-based mesoscopic simulation approach.
  • Incorporated species-dependent diffusion coefficients.
  • Derived theoretical expressions for reactant-dependent diffusion control.

Main Results:

  • Validated the simulation method using bacterial chemotaxis intracellular signaling pathways.
  • Demonstrated the efficiency and accuracy of the proposed approach.
  • Successfully modeled complex diffusion-reaction dynamics.

Conclusions:

  • The novel simulation method offers an efficient and accurate way to model diffusion-influenced reactions.
  • The approach is suitable for complex biological systems like bacterial chemotaxis.
  • This tool advances the simulation of mesoscopic systems with detailed reaction dynamics.