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The renal effects of ALK inhibitors

Hassan Izzedine1, Rania Kheder El-Fekih2, Mark A Perazella3

  • 1Department of Nephrology, Monceau Park International Clinic Paris, Paris, France. hassan.izzedine@clinique-monceau.com.

Investigational New Drugs
|July 30, 2016
PubMed

Insights

Crizotinib, an ALK-1 inhibitor for non-small cell lung cancer, may cause kidney failure and renal cysts. This review details crizotinib

Area of Science:

  • Oncology
  • Pharmacology
  • Nephrology

Background:

  • Anaplastic lymphoma kinase 1 (ALK-1) is a key target in certain cancers.
  • Small molecule inhibitors like crizotinib are used to treat ALK-positive non-small cell lung cancer (NSCLC).
  • Understanding drug-induced toxicities is crucial for patient safety.

Purpose of the Study:

  • To review the adverse renal effects associated with crizotinib treatment in clinical practice.
  • To highlight potential kidney complications in patients receiving crizotinib for ALK-positive NSCLC.

Main Methods:

  • Literature review of package inserts and published studies on crizotinib.
  • Focus on clinical observations and reported adverse events related to renal function.

Main Results:

  • Crizotinib is associated with an increased risk of kidney failure.
  • Renal cyst development and progression are potential adverse effects.
  • Peripheral edema and electrolyte disturbances are also noted.

Conclusions:

  • Clinicians should monitor renal function closely in patients treated with crizotinib.
  • Awareness of potential nephrotoxicity is essential for managing ALK-positive NSCLC patients.
  • Further research may be needed to elucidate mechanisms and mitigate renal side effects.
Keywords:
ALK-1Anaplastic lymphoma kinaseCrizotinibCystOnco-nephrologySerum creatinine

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