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Updated: Mar 17, 2026

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics
Published on: August 27, 2013
Utilizing on- and off-line monitoring tools to follow a kinetic resolution step during flow synthesis
Kathleen A Farley1, Usa Reilly1, Dennis P Anderson1
1Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States.
Abstract:
In situ reaction monitoring tools offer the ability to track the progress of a synthetic reaction in real time to facilitate reaction optimization and provide kinetic/mechanistic insight. Herein, we report the utilization of flow NMR, flow IR, and other off-line spectroscopy tools to monitor the progress of a flow chemistry reaction. The on-line and off-line tools were selected to facilitate the stereoselective kinetic resolution of a key racemic monomer, which lacked a chromophore, making conventional reaction monitoring difficult. Copyright © 2016 John Wiley & Sons, Ltd.
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