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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Unrenewable Cells00:50

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In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
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Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells
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Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells

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[Stem Cells for Retina Replacement].

I P Seitz1, K Achberger2, S Liebau2

  • 1Universitäts-Augenklinik, Department für Augenheilkunde, Universitätsklinikum Tübingen.

Klinische Monatsblatter Fur Augenheilkunde
|August 2, 2016
PubMed
Summary
This summary is machine-generated.

Regenerative medicine offers new hope for end-stage retinal degeneration. Advances in cell-based therapies and artificial retinal tissue show promise for transplantation, overcoming previous obstacles.

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Cell-based Therapies

Background:

  • Cell-based treatments show therapeutic potential for end-stage retinal degeneration.
  • Corneal transplantation is successful, but retinal transplantation faces significant challenges.
  • Obstacles include producing suitable retinal transplants and achieving functional integration.

Purpose of the Study:

  • To review progress in regenerative medicine for retinal degeneration.
  • To discuss the clinical utility of artificial retinal tissue and cell-based strategies.
  • To highlight advancements in autologous transplant production using induced pluripotency.

Main Methods:

  • Review of current research in artificial retinal tissue development.
  • Analysis of cell-based treatment strategies for retinal diseases.
  • Exploration of new technologies for autologous transplant production.

Main Results:

  • New technologies enable autologous transplant production via induced pluripotency.
  • Artificial retinal tissue is under development for research and transplantation.
  • Significant progress is being made in regenerative ophthalmology.

Conclusions:

  • Cell-based therapies and artificial retinal tissue are promising for retinal degeneration.
  • Overcoming challenges in transplant production and integration is key for clinical use.
  • Regenerative medicine is rapidly advancing in ophthalmology.