Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.6K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.6K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

8.3K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
8.3K
Vaccinations01:51

Vaccinations

51.0K
Overview
51.0K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.1K
Overview
83.1K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.3K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Envisioning the development of a CRISPR-Cas mediated base editing strategy for a patient with a novel pathogenic <i>CRB1</i> single nucleotide variant.

Ophthalmic genetics·2022
Same author

[Stem Cells for Retina Replacement].

Klinische Monatsblatter fur Augenheilkunde·2016
Same author

[Gene therapy as a treatment concept for inherited retinal diseases].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2015
Same author

[Stem cell therapy for retinal diseases].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2015
Same author

In vivo biocompatibility of a new cyanine dye for ILM peeling.

Eye (London, England)·2014
Same author

[Spectral domain optical coherence tomography in the treatment of myopic choroidal neovascularization].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2012
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jan 1, 2026

A Step-By-Step Method to Detect Neutralizing Antibodies Against AAV using a Colorimetric Cell-Based Assay
05:53

A Step-By-Step Method to Detect Neutralizing Antibodies Against AAV using a Colorimetric Cell-Based Assay

Published on: December 7, 2021

5.2K

Innate Immune Response Following AAV Administration.

D L Dauletbekov1, J K Pfromm1, A K Fritz1

  • 1University Eye Hospital and Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany.

Advances in Experimental Medicine and Biology
|December 30, 2019
PubMed
Summary
This summary is machine-generated.

Recombinant adeno-associated virus (rAAV) gene therapy faces immune challenges. Understanding innate immunity to rAAV is crucial for improving its safety and effectiveness in clinical gene delivery applications.

Keywords:
AAVGene therapyInnate immune response

More Related Videos

Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice
08:17

Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice

Published on: February 15, 2019

39.0K
Influenza A Virus Studies in a Mouse Model of Infection
10:44

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

29.6K

Related Experiment Videos

Last Updated: Jan 1, 2026

A Step-By-Step Method to Detect Neutralizing Antibodies Against AAV using a Colorimetric Cell-Based Assay
05:53

A Step-By-Step Method to Detect Neutralizing Antibodies Against AAV using a Colorimetric Cell-Based Assay

Published on: December 7, 2021

5.2K
Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice
08:17

Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice

Published on: February 15, 2019

39.0K
Influenza A Virus Studies in a Mouse Model of Infection
10:44

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

29.6K

Area of Science:

  • * Gene therapy and viral vector immunology.
  • * Innate and adaptive immune responses to viral vectors.

Background:

  • * Recombinant adeno-associated virus (rAAV) is a highly efficient gene delivery vector, particularly for postmitotic cells.
  • * Host immune responses, especially adaptive immunity, can restrict the therapeutic efficacy of rAAV in clinical settings.
  • * Innate immune responses represent the initial defense against viral vectors and significantly influence subsequent adaptive immunity.

Purpose of the Study:

  • * To provide a comprehensive overview of the innate immune responses elicited by rAAV vectors.
  • * To highlight the importance of understanding innate immunity for enhancing rAAV safety and therapeutic potential.

Main Methods:

  • * Literature review of studies investigating innate immune responses to rAAV.
  • * Analysis of mechanisms by which innate immune cells interact with and respond to rAAV vectors.

Main Results:

  • * Innate immune responses are critical in the early stages of rAAV administration.
  • * These responses can shape the overall immune profile, impacting therapeutic outcomes.
  • * Specific innate immune pathways activated by rAAV are being elucidated.

Conclusions:

  • * A deeper understanding of innate immune responses to rAAV is essential for optimizing gene therapy strategies.
  • * Targeting or modulating innate immunity may overcome limitations associated with rAAV gene delivery.
  • * This knowledge can lead to improved safety and efficacy of rAAV-based therapeutics.