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Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine

Jenny Rackwitz1, Janina Kopyra2, Iwona Dąbkowska3

  • 1Institute of Chemistry-Physical Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam, Germany.

Angewandte Chemie (International Ed. in English)
|August 3, 2016
PubMed
Summary

2-Fluoroadenine (2F)A enhances DNA strand breakage when exposed to low-energy electrons, acting as an effective radiosensitizer for cancer radiotherapy across various electron energies.

Keywords:
DNA origamiDNA radiation damageab initio calculationsdissociative electron attachmentfludarabine

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