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Related Experiment Videos

Second-generation consequences of small-for-dates birth.

M A Klebanoff1, O Meirik, H W Berendes

  • 1Prevention Research Program, National Institute of Child Health and Human Development, Bethesda, MD 20892.

Pediatrics
|August 1, 1989
PubMed
Summary
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Women who were small for gestational age (SGA) at birth are more likely to have SGA infants. These women also face a higher risk of delivering preterm infants, indicating intergenerational effects of intrauterine growth.

Area of Science:

  • Reproductive Health
  • Perinatal Epidemiology
  • Maternal-Fetal Medicine

Background:

  • Understanding the long-term implications of fetal growth on subsequent generations is crucial for perinatal care.
  • Previous research has not extensively examined the birth outcomes of women based on their own recorded birth characteristics.

Purpose of the Study:

  • To investigate the association between a woman's own birth weight and gestational age and the birth outcomes of her children.
  • To determine if being small for gestational age (SGA) or preterm at birth influences the risk of having an SGA or preterm infant.

Main Methods:

  • A retrospective cohort study involving 1154 Swedish women born between 1955 and 1965.
  • Analysis of birth outcomes (gestational age and birth weight) for births occurring between 1972 and 1983.

Related Experiment Videos

  • Calculation of odds ratios and confidence intervals to assess risk.

    • Main Results:

    • Women who were small for gestational age (SGA) at birth had a significantly increased risk of giving birth to an SGA infant (OR = 2.21).
    • Women who were SGA also had a substantially higher risk of delivering a preterm infant (OR = 2.96).
    • Being born preterm did not significantly increase the risk of giving birth to preterm or SGA infants.

    Conclusions:

    • Intrauterine growth retardation may have lasting effects that can be transmitted to the next generation.
    • Women with a history of being small for gestational age (SGA) should be considered at elevated risk for delivering both growth-retarded and preterm infants.
    • These findings highlight the importance of considering maternal birth history in prenatal care and risk assessment.