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Redox-responsive alginate microsphere containing cystamine.

Kyeongnan Kwon1, Jin-Chul Kim1

  • 1a Department of Medical Biomaterials Engineering , College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University , Chuncheon , Republic of Korea.

Journal of Biomaterials Science. Polymer Edition
|August 4, 2016
PubMed
Summary
This summary is machine-generated.

Redox-responsive alginate microspheres were developed using cystamine. Higher cystamine content enhanced dye release, particularly in the presence of reducing agents like dithiothreitol (DTT).

Keywords:
Redoxalginatecystamineemulsionmicrosphererelease

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Alginate is a widely used natural polymer for developing drug delivery systems.
  • Developing stimuli-responsive materials is crucial for targeted drug release.
  • Cystamine offers redox-responsive properties due to its disulfide bond.

Purpose of the Study:

  • To prepare and characterize redox-responsive alginate microspheres.
  • To investigate the effect of cystamine content on microsphere properties and drug release.
  • To evaluate the influence of reducing agents on the release kinetics.

Main Methods:

  • Preparation of alginate-cystamine microspheres via O/W emulsion solidification with calcium ions.
  • Characterization using Scanning Electron Microscopy (SEM) and Energy-Dispersive X-ray Spectroscopy (EDS).
  • In vitro release studies of blue dextran in the presence of varying dithiothreitol (DTT) concentrations.

Main Results:

  • Spherical microspheres with diameters < 1 μm were successfully prepared.
  • Sulfur content increased with higher cystamine ratios, consistent with EDS analysis.
  • Blue dextran release was higher with increased cystamine content and showed DTT concentration-dependent release at higher cystamine levels.
  • Alginate cross-linking by cystamine was observed, with disulfide bond breakdown by DTT.

Conclusions:

  • Alginate-cystamine microspheres exhibit tunable redox-responsive behavior.
  • The disulfide bonds in cystamine are key to the DTT-triggered release mechanism.
  • These microspheres show potential for controlled drug delivery applications sensitive to redox environments.