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Updated: Mar 16, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
Published on: August 29, 2012
Graft-versus-host disease: unexpected presentation with simultaneous hepatitis and pancreatitis
Samuel Raimundo Fernandes1, Antonio T Alves2, Margarida Barreto Cortes3
1Serviço de Gastrenterologia e Hepatologia, Hospital de Santa Maria, Lisbon, Portugal.
Abstract:
We report the case of a 37-year-old man with a previous bone marrow transplantation presenting with abdominal pain, diarrhoea and jaundice. Laboratory evaluation showed marked elevated liver enzymes, amylase and lipase with ultrasonographic evidence of acute alithiasic pancreatitis. Liver biopsy was compatible with graft-versus-host disease and toxic hepatitis. The patient rapidly improved after increasing immunosuppression. Although gastrointestinal manifestations are common in graft-versus-host disease, clinical acute pancreatitis is rarely seen. Patients with graft versus host are seldom managed by gastroenterologists and hepatologists. An awareness of this condition is essential for the experienced clinician.
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