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Glioblastoma Multiforme with Hypodipsic Hypernatremia in a Seven-Month-Old Golden Retriever
Stephanie Engel1, Karen Marie Hilling1, Travis Kuder Meuten1
1From the Clinical Sciences Department (S.E.); the Microbiology, Immunology and Pathology Department, College of Veterinary Medicine and Biomedical Sciences (T.K.M., C.B.F.); and the Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences (A.J.M.), Colorado State University, Fort Collins, CO; and the Animal Hospital Specialty Center, Highlands Ranch, CO (K.M.H.).
Abstract:
Primary hypodipsic hypernatremia is a rarely reported disease in dogs. Reported underlying causes associated with this disease in dogs include congenital malformations, encephalitis, intracranial neoplasia, and pressure atrophy of the hypothalamus secondary to hydrocephalus. The dog in this report had an infiltrative neoplastic disorder, likely causing damage to the hypothalamic osmoreceptors responsible for the thirst generation. The neoplastic process was identified histopathologically as glioblastoma multiforme, an unusual tumor to occur in a dog this young. A tumor of the central nervous system causing physical destruction of the osmoreceptors has rarely been reported in dogs and none of the previously reported cases involved a glial cell tumor.
