Cytologic findings in vaginal smears from patients under treatment with cyclophosphamide

A report is given on the vaginal smears of 55 patients with ovarian carcinomas who were treated with cyclophosphamide either alone or in combination with other therapies. The changes occurring under the treatment are demonstrated and compared with the findings before therapy. A shift to lesser maturation depending upon drug dose and the appearance of the so-called "polychromatic and polymorphous near type" are described. This smear type was found in about 60 per cent of all cases and was reversible after cessation of the therapy. The characteristics of the "polychromatic and polymorphous smear type" are presented.