Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Mar 16, 2026

Intravitreous Injection for Establishing Ocular Diseases Model

Intravitreous Injection for Establishing Ocular Diseases Model

Published on: October 1, 2007

CLINICAL EVALUATION OF THE RAPID ACCESS VITREAL INJECTION GUIDE: A Handheld Instrument for Assisting Intravitreal

Dennis P Han¹, Kaitlin C McKenney, Judy E Kim

¹*Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin; †Departments of Ophthalmology and Visual Sciences, and Epidemiology, University of Michigan, Ann Arbor, Michigan; and ‡Retina Associates, PA, Shawnee Mission, Kansas.

Retina (Philadelphia, Pa.)

|August 5, 2016

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diabetic Retinopathy Outcomes Among Unhoused Individuals: A Big Data Analysis.

Retina (Philadelphia, Pa.)·2026

Same author

Deep UV Resonance Raman Spectroscopy: Applications to Membrane Proteins and Peptides.

Methods in molecular biology (Clifton, N.J.)·2026

Same author

Deep learning strategies for estimating retinal thickness from fundus images: a comparative study with multi-device data.

Scientific reports·2026

Same author

Comprehensive Adult Medical Eye Evaluation Preferred Practice Pattern®.

Ophthalmology·2026

Same author

Activating Solid-State Triplet-Triplet Annihilation Upconversion via Bulky Annihilators.

Journal of the American Chemical Society·2026

Same author

Direct Optical Quantification of Chain Collapse, Reduced Dielectric, and Water Release Driving Protein Phase Separation.

bioRxiv : the preprint server for biology·2025

Same journal

Persistent placoid maculopathy: long term outcomes and prognostic factors.

Retina (Philadelphia, Pa.)·2026

Same journal

ANTI-VEGF THERAPY SWITCHING RETINAL DISEASES: Characterizing Clinical Manifestations and Common Involved Genes: ERRATUM.

Retina (Philadelphia, Pa.)·2026

Same journal

THE EFFICACY AND SAFETY OF SUBRETINAL BALANCED SALT SOLUTION INJECTION IN DIABETIC MACULAR EDEMA WITH HARD EXUDATES: ERRATUM.

Retina (Philadelphia, Pa.)·2026

Same journal

EVALUATING CLINICAL OUTCOMES OF AMNIOTIC MEMBRANE COVERAGE COMBINED WITH EARLY VITRECTOMY IN THE MANAGEMENT OF PERFORATING GLOBE INJURIES.

Retina (Philadelphia, Pa.)·2026

Same journal

Mid-Phase Hyperfluorescent Plaques as a biomarker of disease activity in Central Serous Chorioretinopathy: Clinical Course and Treatment Response - MICRoN report number Ten.

Retina (Philadelphia, Pa.)·2026

Same journal

Severe retinal non-perfusion is associated with fewer retinal lesions on ultra-wide field fundus photography in proliferative diabetic retinopathy.

Retina (Philadelphia, Pa.)·2026

See all related articles

The Rapid Access Vitreal Injection (RAVI) guide is as effective as traditional tools for intravitreal injections, achieving operative goals with similar low pain scores and potentially enhancing safety and efficiency.

Area of Science:

Ophthalmology
Surgical Instrumentation
Medical Device Evaluation

Background:

Intravitreal injections are common ophthalmic procedures.
Current methods often use separate eyelid speculums and measuring calipers.
A novel combined instrument, the Rapid Access Vitreal Injection (RAVI) guide, has been developed.

Purpose of the Study:

To clinically evaluate the RAVI guide for intravitreal injections.
To assess patient acceptance and complication rates associated with the RAVI guide.
To compare the RAVI guide's performance against traditional speculum/caliper use.

Main Methods:

A prospective study involving 54 patients undergoing intravitreal injections.
Comparison between the RAVI guide (n=32) and conventional speculum/caliper (n=22).

More Related Videos

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Related Experiment Videos

Last Updated: Mar 16, 2026

Intravitreous Injection for Establishing Ocular Diseases Model

Intravitreous Injection for Establishing Ocular Diseases Model

Published on: October 1, 2007

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Pain assessment using the Wong-Baker scale (0-10); operative goals tracked.

Main Results:

No significant difference in mean device-related pain scores between RAVI (0.6) and speculum (0.7) groups.
Higher rate of significant pain (≥2) in the speculum group (32%) vs. RAVI group (16%), though not statistically significant.
All operative goals, including precise needle guidance and avoiding lid/lash contact, were met for all patients.

Conclusions:

The RAVI guide is equivalent to the eyelid speculum in achieving key operative goals.
Patient-reported pain levels were similarly low for both devices.
The RAVI guide shows potential for improving efficiency, accuracy, and safety in intravitreal injections.