Local Optima in Mixture Modeling
Emilie M Shireman1, Douglas Steinley1, Michael J Brusco2
1a University of Missouri.
Abstract:
It is common knowledge that mixture models are prone to arrive at locally optimal solutions. Typically, researchers are directed to utilize several random initializations to ensure that the resulting solution is adequate. However, it is unknown what factors contribute to a large number of local optima and whether these coincide with the factors that reduce the accuracy of a mixture model. A real-data illustration and a series of simulations are presented that examine the effect of a variety of data structures on the propensity of local optima and the classification quality of the resulting solution. We show that there is a moderately strong relationship between a solution that has a high proportion of local optima and one that is poorly classified.
Related Concept Videos
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Mechanistic Models: Compartment Models in Individual and Population Analysis
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Maxwell-Boltzmann Distribution: Problem Solving
This distribution function f(v) is defined by saying that the expected number N (v1,v2) of particles with speeds between v1 and v2 is given by


