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Updated: Mar 16, 2026

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
Published on: April 17, 2012
Magnetic Materials for the Selective Analysis of Peptide and Protein Biomarkers
Susy Piovesana, Anna Laura Capriotti1
1Department of Chemistry, Faculty of Mathematical, Physical and Natural Sciences, Sapienza Università di Roma, P.O. Box: Piazzale Aldo Moro 5, 00185, Rome. Italy.
Abstract:
This mini-review article provides an overview on the use of magnetic materials for the analysis of protein biomarkers. In particular, the advantage provided by magnetic solid phase extraction will be discussed with selected examples, considering untargeted analysis for screening new biomarker proteins and targeted investigation on known and suggested new biomarkers. Aspects, such as enrichment efficiency over conventional techniques, ease of use, functionalization versatility and automation will be considered, together with quantification and deeper structure elucidation provided by coupling selective or specific enrichment to powerful characterization techniques, such as mass spectrometry.
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