Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Area of Science:

• Oncology
• Genetics
• Hereditary Cancer Syndromes

Background:

• Lynch syndrome is the most frequent cause of hereditary colorectal cancer.
• It stems from germline mutations in DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2) or EPCAM deletions.
• Individuals with Lynch syndrome face elevated lifetime risks for colorectal, endometrial, ovarian, and stomach cancers.

Purpose of the Study:

• To provide an update on the latest NCCN Guidelines for Lynch syndrome diagnosis and management.
• To emphasize current recommendations for screening and surveillance.

Main Methods:

• Review of the most current NCCN Guidelines.
• Focus on diagnostic criteria and management strategies for Lynch syndrome.

Main Results:

• The NCCN panel recommends screening all patients diagnosed with colorectal cancer for Lynch syndrome.
• Recommendations are provided for surveillance protocols aimed at early detection and prevention of Lynch syndrome-associated malignancies.

Conclusions:

• Prompt diagnosis and management of Lynch syndrome are crucial for reducing cancer risk.
• Universal screening for Lynch syndrome in colorectal cancer patients is advised.
• Regular surveillance can improve outcomes for individuals with Lynch syndrome.