Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Independent Predictors Associated with Patient Refusal of Invasive Diagnostic Procedures After Positive LDCT Lung Cancer Screening.

Diagnostics (Basel, Switzerland)·2026

Same author

Impact of patient and tumor characteristics on various aspects of the non-small cell lung cancer patient journey in Romania, Bulgaria, Serbia: A multicenter, non-interventional, retrospective cohort study.

Cancer treatment and research communications·2025

Same author

Embedded hardware-based adaptive filtering for noise reduction in bioimpedance data.

Computers in biology and medicine·2025

Same author

Effects of Etching and Delamination on Biocompatibility of Ti-Based MXenes.

ACS applied materials & interfaces·2025

Same author

Inter-lower limb and intra-lower limb muscle activity correlations during walking: A comparative study of stroke patients and healthy individuals.

PloS one·2025

Same author

Health literacy and socioeconomic characteristics of young people in Serbia and their influence on reproductive health and sexual behaviour.

Central European journal of public health·2025

Search research articles

Related Experiment Video

Updated: Mar 16, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

CHEMOTHERAPY ANALYSIS IN MASSIVE TRANSFUSION SYNDROME.

Bratislav Stanković, Goran Stojanović

Medicinski Pregled

|August 9, 2016

Summary

Massive transfusion protocols aim to restore hemostasis in acute bleeding. This study evaluated chemotherapy

Area of Science:

Critical Care Medicine
Hematology
Surgical Oncology

Background:

Massive transfusion involves replacing a patient's total blood volume within 3-4 hours.
Acute massive bleeding presents significant hemostatic challenges.
Dilutional coagulopathy is a known complication of large-volume red blood cell transfusions.

Purpose of the Study:

To analyze the application of chemotherapy in managing patients with acute massive bleeding.
To evaluate the effectiveness of hemostasis and platelet counts in patients undergoing massive transfusions.

Main Methods:

Twenty-four patients with acute massive bleeding received comprehensive hemostatic factor compensation.
Treatment involved stopping surgical bleeding followed by combined transfusion of red blood cells, fresh frozen plasma, cryoprecipitates, and platelet concentrate.

More Related Videos

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

Related Experiment Videos

Last Updated: Mar 16, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

Therapeutic goals included maintaining normal circulating blood volume, blood pressure, hemoglobin, and hematocrit levels.

Main Results:

Patients received an average of 16-18 units of red blood cells, 980-1220 ml of fresh frozen plasma, 10-15 units of cryoprecipitates, and 8-12 units of platelet concentrate.
Transfusion volumes ranged significantly, indicating tailored treatment approaches.

Conclusions:

The study confirmed that large-volume red blood cell transfusions lead to dilutional coagulopathy.
A significant decrease in platelet count and reduced activity of coagulation factors were observed post-transfusion.