Cutaneous peripheral T-cell lymphoma, not otherwise specified: A single-center prognostic analysis

Area of Science:

• Oncology
• Dermatology
• Hematology

Background:

• Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is an aggressive hematologic malignancy.
• Cutaneous involvement is a significant presentation of PTCL-NOS.

Purpose of the Study:

• To evaluate clinical, histopathologic, and prognostic factors in patients with PTCL-NOS affecting the skin.
• To identify predictors of survival in cutaneous PTCL-NOS.

Main Methods:

• Retrospective chart review of patients diagnosed with cutaneous PTCL-NOS between 1993 and 2013.
• Analysis of patient demographics, disease characteristics, and survival data.

Main Results:

• Thirty patients with cutaneous PTCL-NOS were analyzed; 14 had skin-only disease, and 15 had concurrent skin and systemic disease.
• For primary cutaneous PTCL-NOS, the 5-year overall survival was 61% with a median survival of 5.6 years.
• Patients with concurrent disease had a significantly poorer prognosis, with a 5-year survival of 29% and a median survival of 3.9 years.

Conclusions:

• Age at diagnosis and presence of B-symptoms are significant predictors of poor survival.
• Multifocal lesions and concomitant systemic PTCL-NOS indicate a worse prognosis.