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Rosacea and gastrointestinal disorders: a population-based cohort study
A Egeberg1, L B Weinstock2, E P Thyssen2
1Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Kildegårdsvej 28, 2900, Hellerup, Denmark.
The British Journal of Dermatology
|August 9, 2016
Summary
This study found that rosacea is linked to several gastrointestinal disorders, including coeliac disease, Crohn disease, ulcerative colitis, and irritable bowel syndrome. These findings suggest a connection between skin health and gut health that warrants further investigation.
Area of Science:
- Dermatology
- Gastroenterology
- Epidemiology
Background:
- Rosacea is a common inflammatory skin condition with potential links to gastrointestinal disorders.
- Existing data on the association between rosacea and gastrointestinal diseases are limited.
Purpose of the Study:
- To investigate the association between rosacea and specific gastrointestinal conditions: coeliac disease (CeD), Crohn disease (CD), ulcerative colitis (UC), Helicobacter pylori infection (HPI), small intestinal bacterial overgrowth (SIBO), and irritable bowel syndrome (IBS).
Main Methods:
- A nationwide cohort study involving 49,475 rosacea patients and 4,312,213 controls.
- Utilized nationwide administrative registers for patient identification and data collection.
- Employed Cox regression analysis to determine hazard ratios (HRs) for new-onset gastrointestinal disorders in rosacea patients.
Main Results:
- Prevalence of CeD, CD, UC, and IBS was significantly higher in rosacea patients compared to controls.
- Adjusted HRs indicated significant associations between rosacea and CeD (HR 1.46), CD (HR 1.45), UC (HR 1.19), and IBS (HR 1.34).
- No significant association was found between rosacea and HPI (HR 1.04) or SIBO (HR 0.71).
Conclusions:
- Rosacea is associated with specific gastrointestinal diseases, though the underlying pathogenic mechanism remains unclear.
- The findings highlight a potential link between rosacea and gastrointestinal health.
- Clinicians should consider gastrointestinal issues in patients presenting with rosacea.
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