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Related Concept Videos

Trihybrid Crosses02:27

Trihybrid Crosses

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Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
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Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
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Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
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Genotypes, Networks, Phenotypes: Moving Toward Plant Systems Genetics.

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Understanding the genetic basis of organismal traits requires integrating systems biology and quantitative genetics. Systems genetics bridges this gap, advancing our knowledge of plant development and quantitative trait variation.

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Area of Science:

  • Genetics and Genomics
  • Developmental Biology
  • Plant Science

Background:

  • Identifying genes crucial for organismal processes is ongoing, but the genetic underpinnings of quantitative phenotypic differences in natural populations remain largely unknown.
  • A significant gap exists between experimental genetics findings and the broader understanding needed for the genotype-to-phenotype problem.

Purpose of the Study:

  • To address the genotype-to-phenotype problem by integrating systems biology and quantitative genetics.
  • To highlight advances in understanding developmental processes like flowering time and root growth through systems genetics.

Main Methods:

  • Combining systems biology approaches with quantitative genetics to study natural variation.
  • Analyzing genetic bases for quantitative phenotypic differences in natural populations.

Main Results:

  • Significant advances have been made in understanding flowering time control and root growth.
  • Demonstrated the utility of systems genetics in dissecting complex traits.

Conclusions:

  • Systems genetics offers a powerful framework for bridging the gap between genotype and phenotype.
  • Efforts in systems genetics, particularly in plants, are crucial for understanding quantitative trait variation and development.