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Published on: January 16, 2015
A longitudinal study of skin barrier function in pregnancy and the postnatal period
Aine Gallagher1, Jonathan O'B Hourihane2, Louise C Kenny1
1The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland.
Background:
It is unknown whether skin's barrier function changes in pregnancy. Trans Epidermal Water Loss (TEWL) refers to the total amount of water loss through the skin and TEWL can be measured non-invasively as an index of skin barrier function. We measured TEWL during and after pregnancy to evaluate pregnancy-related skin barrier function.
Methods:
This was a prospective, longitudinal cohort study of 52 low-risk, first-time pregnant women nested within the Screening for Pregnancy Endpoints (SCOPE) Ireland study. TEWL (gwater/m2/h) was measured three times during pregnancy: 19-21 weeks, 27-32 weeks and 36 weeks; and three times postnatally: 2-4 days, 2 months and 6 months post-delivery. Data were analysed using SPSS 18.0 and P > 0.05 was considered statistically significant.
Results:
A rise in TEWL was seen between each visit with the highest readings, exceeding the normal range of 0-20 gwater/m(2)/h, recorded at two months post-delivery. Forty women attended at two months post-delivery of whom 22 women had an average reading between 0 and 20 gwater/m(2)/h; 10 women had an average reading between 21 and 40 gwater/m(2)/h and 8 women had an average reading between 41 and 75 gwater/m(2)/h. Readings had returned to an average of 0-20 gwater/m(2)/h at six months postnatally.
Conclusion:
TEWL increases slightly in pregnancy and the postnatal period. The clinical significance of this is unclear and requires further investigation.
