[PROGNOSTIC MODELS IN MODERN MANAGEMENT OF VULVAR CANCER].

Area of Science:

• Gynecologic Oncology
• Surgical Oncology
• Pathology

Context:

• Squamous cell vulvar carcinoma (SCVC) is a rare gynecologic malignancy.
• Accurate prognosis and identification of prognostic factors are crucial for effective patient management.
• Individualized surgical approaches aim to optimize outcomes while minimizing morbidity.

Purpose:

• To evaluate prognosis and prognostic factors in SCVC patients undergoing primary surgery.
• To analyze the influence of clinicopathological characteristics on overall survival (OS) and recurrence-free survival (RFS).
• To develop prognostic models for OS and RFS based on identified factors.

Summary:

• A cohort of 113 SCVC patients treated between 2000-2010 with individualized surgical techniques were analyzed.
• Univariate and multivariate analyses identified FIGO stage and relapse occurrence as independent predictors of OS.
• Metastatic inguinal nodes, tumor size (>3 cm), and lymphovascular invasion were significant independent predictors of RFS.

Impact:

• The study provides valuable insights into prognostic indicators for SCVC.
• Developed prognostic models can aid in stratifying patients into risk groups for tailored treatment strategies.
• Findings support the importance of surgical staging and detailed clinicopathological assessment in SCVC management.