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Updated: Mar 16, 2026

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
[Analysis of hemoperfusion in the treatment of thinner poisoning effect]
Objective:
To investigate the combination of drugs in blood perfusion-based rescue therapy of acute poisoning thinners.
Methods:
Our department were retrospectively analyzed in May 2011 to October 2014, 54 cases thinners poisoning patients choose the thinner should be 44 cases of acute poisoning patients were divided into two groups. Toluene, xylene group 8 cases; Halogenated hydrocarbon group 34cases; Give blood perfusion 3 to 7 times, compared before and after the blood perfusion of toxicant concentration, results and biochemical indicators.
Results:
By selection of 44 patients with acute thinners poisoning in 42 patients were successfully treated, the cure rate was 96%. And treatment in patients with successful both in toluene, xylene, or halogenated hydrocarbon group after blood perfusion its toxicant concentration significantly decreased; 42 patients blood perfusion treatment of the indexes of liver function after than before treatment significantly improved.
Conclusion:
The early hemoperfusion is a very effective way of acute poisoning thinners currently rescue.
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Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...

