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The Future of Precision Medicine in Oncology

Lori M Millner1, Lindsay N Strotman2

  • 1PGXL Technologies, 201 East Jefferson Street, Suite 306, Louisville, KY 40202, USA; Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA.

Clinics in Laboratory Medicine
|August 13, 2016
PubMed

Insights

Precision medicine revolutionizes cancer care by tailoring treatments to individual genetic profiles. Liquid biopsies offer a minimally invasive way to monitor cancer

Area of Science:

  • Oncology and Molecular Diagnostics

Background:

  • Precision medicine aims to personalize cancer therapy based on tumor genetic makeup.
  • Traditional chemotherapy lacks specificity, affecting both cancerous and healthy rapidly dividing cells.
  • Targeted therapies represent a cornerstone of precision medicine, requiring patient selection for optimal efficacy.

Purpose of the Study:

  • To highlight the role of precision medicine in oncology.
  • To introduce liquid biopsy as a novel tool in cancer management.
  • To explain the components and benefits of liquid biopsy.

Main Methods:

  • Analysis of circulating tumor cells (CTCs).
  • Examination of cell-free nucleic acids (cfNA).
  • Study of exosomes derived from peripheral blood.
  • Serial collection and analysis of these biomarkers, individually or combined.

Main Results:

  • Liquid biopsy provides real-time insights into cancer evolution.
  • Enables dynamic monitoring of treatment response and resistance.
  • Offers a less invasive alternative to traditional tissue biopsies.

Conclusions:

  • Liquid biopsy is a rapidly advancing frontier in precision oncology.
  • It facilitates dynamic patient monitoring and personalized treatment adjustments.
  • Integration of liquid biopsy enhances the precision medicine paradigm in cancer care.
Keywords:
Cell-free nucleic acid (cfNA)Circulating tumor cell (CTC)ExosomesExtracellular vesicle (EV)Liquid biopsyTargeted therapy

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