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Updated: Mar 16, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
Synthetic Hormones and Clot Formation
Albe C Swanepoel1, Amcois Visagie1, Etheresia Pretorius1
1Department of Physiology,School of Medicine, Faculty of Health Sciences,University of Pretoria,Private Bag x323,Pretoria, Arcadia0007,South Africa.
Combined oral contraceptives (COCs) carry risks like venous thrombosis. This study investigates COC effects on blood clot formation, suggesting personalized prescriptions to mitigate health risks in susceptible women.
Area of Science:
- Hematology
- Pharmacology
- Women's Health
Background:
- Combined oral contraceptives (COCs) offer significant benefits for family planning and managing gynecological conditions.
- However, COC use is linked to an increased risk of venous thrombosis, indicating a hypercoagulable state in some individuals.
Purpose of the Study:
- To investigate the health risks associated with combined oral contraceptives (COCs).
- To analyze the impact of different COC constituents on blood clot formation, specifically fibrin network packaging and whole blood viscoelasticity.
Main Methods:
- Utilized viscoelastic and morphological techniques to study clot formation.
- Employed scanning electron microscopy and thromboelastography to examine fibrin packaging and hypercoagulability.
Main Results:
- Whole blood viscoelastic properties exhibited gender-specific variations.
- Morphological alterations in clot formation were individual-specific, irrespective of gender.
Conclusions:
- Viscoelastic and morphological analyses offer insights into fibrin packaging and hypercoagulable state development.
- Proposed a three-step individualized approach: baseline coagulation profiling, tailored COC prescription, and ongoing monitoring to prevent thrombosis risks.
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