Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.0K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

687
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
687
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

100
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
100
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

354
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
354
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

419
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
419
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

641
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
641

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reframing Eczema: Th2-Skewed Contact Sensitization, Atopy Patch Testing, and Systemic Contact Dermatitis.

Current allergy and asthma reports·2026
Same author

Cytokine response to critical illness and its relation to amino acid metabolism.

Clinical nutrition (Edinburgh, Scotland)·2025
Same author

Immunogenicity of Nickel-Further Explored.

Endocrine, metabolic & immune disorders drug targets·2022
Same author

Localized systemic contact dermatitis: The vulva as a clue to identify allergen ingestion.

International journal of women's dermatology·2022
Same author

Evaluation of aspirin platelet inhibition in left ventricular assist device population.

Journal of cardiac surgery·2021
Same author

Disparities in availability of skin therapies found in public assistance formularies.

Journal of the American Academy of Dermatology·2021
Same journal

Centering Lived Experience: Inclusive Pediatric Care for Children Who Are Deaf and Hard of Hearing and Their Families.

Pediatric annals·2026
Same journal

From Early Childhood to Adulthood: Implementing Neuroaffirming Health Care for Autistic Individuals.

Pediatric annals·2026
Same journal

Neurodivergence in Medical Education: Current Landscape and Inclusive Future for Pediatrics.

Pediatric annals·2026
Same journal

Neurodiversity and Intellectual Disability: Opportunities and Challenges for Functioning and Participation Across the Life Course.

Pediatric annals·2026
Same journal

Action for Access: Equity for Children With Disabilities in Lowand Middle-Income Countries.

Pediatric annals·2026
Same journal

Rethinking "Healthy" for Every Child: Building Flexible, Family Centered Routines in a Neurodiverse World.

Pediatric annals·2026
See all related articles

Related Experiment Video

Updated: Mar 16, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.2K

Contact Dermatitis in Pediatrics.

Janice L Pelletier, Caroline Perez, Sharon E Jacob

    Pediatric Annals
    |August 13, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Contact dermatitis, a skin reaction to irritants or allergens, has two main types: irritant and allergic. Management focuses on identifying causes, symptoms, and prevention, especially for children, to reduce exposure to common allergens like nickel.

    More Related Videos

    Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
    09:32

    Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

    Published on: September 26, 2019

    7.7K
    Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
    06:47

    Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

    Published on: September 27, 2017

    10.2K

    Related Experiment Videos

    Last Updated: Mar 16, 2026

    A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
    08:02

    A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

    Published on: March 24, 2023

    5.2K
    Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
    09:32

    Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

    Published on: September 26, 2019

    7.7K
    Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
    06:47

    Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

    Published on: September 27, 2017

    10.2K

    Area of Science:

    • Dermatology
    • Allergology
    • Pediatrics

    Background:

    • Contact dermatitis encompasses skin reactions to noxious or allergenic substances.
    • It presents as two primary types: irritant contact dermatitis and allergic contact dermatitis.

    Purpose of the Study:

    • To review the signs, symptoms, causes, and complications of contact dermatitis.
    • To discuss the testing, treatment, and prevention strategies for contact dermatitis.
    • To highlight avoidance measures for susceptible children and the potential impact of a nickel directive.

    Main Methods:

    • This is a review article.
    • Information was gathered on the clinical presentation, etiology, and management of contact dermatitis.

    Main Results:

    • Contact dermatitis manifests with various signs and symptoms, and can lead to complications if not managed.
    • Effective management involves accurate diagnosis, appropriate treatment, and preventative measures.
    • Reducing exposure to common allergens, such as nickel, is crucial, particularly in pediatric populations.

    Conclusions:

    • Comprehensive understanding and management of contact dermatitis are essential for patient care.
    • Preventative strategies, including allergen avoidance and regulatory measures like a nickel directive, can significantly reduce incidence and severity, especially in children.