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Metabolic Control of Longevity.

Carlos López-Otín1, Lorenzo Galluzzi2, José M P Freije1

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A "metabolic clock" influences aging, with metabolic alterations accelerating the process. Promoting metabolic fitness through interventions like caloric restriction may extend human healthspan.

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Area of Science:

  • Gerontology
  • Metabolism
  • Biochemistry

Background:

  • Aging is associated with accumulating metabolic alterations and reduced biological fitness.
  • Inborn metabolic defects and genetic factors influencing longevity highlight metabolism's role in aging.
  • The nine hallmarks of aging are linked to detrimental metabolic changes.

Purpose of the Study:

  • To explore the concept of a
  • metabolic clock
  • controlling aging.
  • To investigate the impact of metabolic alterations on aging and healthspan.
  • To evaluate the potential of metabolic fitness strategies for extending human healthspan.

Main Methods:

  • Review of existing literature on aging hallmarks and metabolic pathways.
  • Analysis of genetic and lifestyle factors influencing metabolism and aging.
  • Correlation of metabolic alterations with biological fitness and lifespan.

Main Results:

  • Metabolic alterations accumulate with age, suggesting a
  • metabolic clock
  • .
  • Inborn metabolic defects accelerate aging, while longevity genes impact metabolism.
  • Western lifestyle (hypercaloric diet, sedentariness) accelerates aging via metabolic consequences.
  • Caloric restriction demonstrates beneficial metabolic effects and extends lifespan.

Conclusions:

  • Metabolism is a central regulator of the aging process.
  • Metabolic interventions, such as caloric restriction, offer healthspan benefits.
  • Strategies enhancing metabolic fitness hold promise for extending human healthspan.