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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Pulmonary Tuberculosis V01:28

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Pulmonary Tuberculosis IV01:26

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Immunotherapy for tuberculosis: future prospects.

Getahun Abate1, Daniel F Hoft2

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Summary
This summary is machine-generated.

New immunotherapies are needed to combat tuberculosis (TB), a global health crisis. This review explores human-tested immunotherapies to control Mycobacterium tuberculosis infection.

Keywords:
HDTimmunotherapytreatmenttuberculosis

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Area of Science:

  • Microbiology
  • Immunology
  • Public Health

Background:

  • Tuberculosis (TB) remains a significant global health issue, with millions infected by Mycobacterium tuberculosis annually.
  • Current treatment and prophylactic regimens for TB are lengthy and challenged by rising drug resistance.
  • There is a critical need for novel therapeutic strategies, including immunotherapies, to manage TB effectively.

Purpose of the Study:

  • To review potential immunotherapies for latent and active tuberculosis.
  • To focus on immunotherapies that have undergone human testing.
  • To highlight strategies for controlling Mycobacterium tuberculosis replication.

Main Methods:

  • Literature review of existing studies on TB immunotherapies.
  • Analysis of immunotherapies tested in human clinical trials.
  • Evaluation of immunotherapy mechanisms against Mycobacterium tuberculosis.

Main Results:

  • Several types of immunotherapies show promise in modulating the immune system against TB.
  • Human-tested immunotherapies offer potential for better control of M. tuberculosis.
  • The review synthesizes current data on the efficacy and application of these therapies.

Conclusions:

  • Immunotherapies represent a promising avenue for adjunct or alternative treatment for TB.
  • Further research and development of immunotherapies are crucial for combating the global TB burden.
  • Targeting the host immune response can complement traditional anti-TB drug regimens.