Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

RNA Stability

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...

RNA Stability

RNA Stability

Nuclear Export of mRNA

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Ribosomal RNA Synthesis

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Psychosocial adversity captured by ICD-10 Z-codes and mortality risk: evidence from the UK Biobank.

GeroScience·2026

Same author

Longitudinal analysis of cytokines, chemokines, and inflammatory markers in a middle-aged cohort.

GeroScience·2026

Same author

Leisure activity engagement, spirituality, and cognitive function in middle-aged and older Black adults.

The journals of gerontology. Series B, Psychological sciences and social sciences·2026

Same author

Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults.

Aging cell·2026

Same author

Prognostic value of PREVENT, PCE, and social determinants of health for cardiovascular mortality in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study.

BMC public health·2026

Same author

A telomere-lipid-immunity axis linking viral integration to autoimmune disease risk.

GeroScience·2026

Search research articles

Related Experiment Video

Updated: Mar 16, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

Extracellular RNA in aging.

Douglas F Dluzen¹, Nicole Noren Hooten¹, Michele K Evans¹

¹Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

Wiley Interdisciplinary Reviews. RNA

|August 18, 2016

Summary

This summary is machine-generated.

Extracellular RNA (exRNA) in bodily fluids shows age-related changes, with microRNAs (miRNAs) potentially indicating aging and disease. Further research is needed to validate exRNAs as biomarkers for aging and related conditions.

More Related Videos

Characterization of Amyloid Structures in Aging C. Elegans Using Fluorescence Lifetime Imaging

Characterization of Amyloid Structures in Aging C. Elegans Using Fluorescence Lifetime Imaging

Published on: March 27, 2020

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Related Experiment Videos

Last Updated: Mar 16, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

Characterization of Amyloid Structures in Aging C. Elegans Using Fluorescence Lifetime Imaging

Characterization of Amyloid Structures in Aging C. Elegans Using Fluorescence Lifetime Imaging

Published on: March 27, 2020

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Area of Science:

Molecular Biology
Genetics
Biochemistry

Background:

Extracellular RNA (exRNA) found in circulation and bodily fluids offers potential as biomarkers for health and disease.
Various exRNA species, including mRNA and noncoding RNAs like miRNA, have been identified.

Purpose of the Study:

To review the current landscape of exRNA profiling in diverse body fluids.
To discuss age-related alterations in exRNA abundance observed in humans and model organisms.
To highlight the role of specific microRNAs (miRNAs) in age-related phenotypes and diseases.

Main Methods:

Review of existing literature on exRNA profiling and age-related changes.
Focus on microRNA (miRNA) research within the context of aging.
Analysis of challenges and validation strategies for exRNA biomarkers.

Main Results:

Age-related changes in exRNA abundance are documented across species.
Specific miRNAs are implicated in aging processes and associated diseases.
Significant research efforts are directed towards understanding exRNA functions in aging.

Conclusions:

Extracellular RNAs, particularly miRNAs, represent a promising area for aging and disease biomarker development.
Addressing current challenges in exRNA validation is crucial for clinical translation.
Continued research is essential to fully elucidate the role of exRNAs in aging and age-related pathologies.