Related Experiment Video
Updated: Mar 16, 2026
08:30
Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
Published on: January 19, 2019
9.7K
DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules
Tuan Trinh1, Pongphak Chidchob, Hassan S Bazzi
1Department of Chemistry and Center for Self-Assembled Chemical Structures, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A 0B8. hanadi.sleiman@mcgill.ca.
Chemical Communications (Cambridge, England)
|August 18, 2016
Abstract:
We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.
