Related Experiment Video
Updated: Mar 16, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
New Cytotoxic Guaianolides from Centaurea aegyptiaca
Abstract:
The ethanol extract of Centaurea aegyptiaca aerial parts afforded two new chlorinated bioactive guaianolides, cenegyptin A (1) and cenegyptin B (2), in addition to four known sesquiterpenes (3 - 6). Their identities were established on the basis of their spectral data. The cytotoxicity (IC50, μM) of compounds 1 - 6 were evaluated against hepatic (HEPG2) and laryngeal (HEP2) carcinoma cell lines in comparison with normal fibroblasts (BHK). Compound 1 showed cytotoxic activity against HEPG2 and HEP2 with IC50 values of 7.2 ± 0.04 and 7.5 ± 0.02, respectively. However, compound 2 exhibited only a limited toxicity against both cell lines.
Related Concept Videos
Drugs that Destabilize Microtubules
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
