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Treatment of aphthae with thalidomide
D Grinspan1, G F Blanco, S Agüero
1Dermatology Unit, Güemes Institute, Buenos Aires, Argentina.
Journal of the American Academy of Dermatology
|June 1, 1989
Summary
Thalidomide effectively treated major and minor aphthae, with 34% achieving a cure and the rest showing improvement. Side effects were minimal and reversible, but teratogenicity necessitates caution in women of childbearing potential.
Area of Science:
- Oral Medicine
- Dermatology
- Pharmacology
Background:
- Recurrent aphthous stomatitis presents a therapeutic challenge.
- Thalidomide has shown efficacy in various inflammatory conditions.